SNAP-8
- Skin & hair
A topical cosmetic peptide used in formulations aimed at the look of expression lines.
Read the published research →What SNAP-8 does
SNAP-8 is a synthetic eight-residue peptide whose sequence copies a short stretch of SNAP-25, the protein nerve endings use to release the signal that tells a muscle to contract. It is supplied to the cosmetic industry as an anti-wrinkle raw material, on the idea that a look-alike peptide competes with the real protein and softens the small repeated contractions that etch expression lines. What has been measured is the finished formulations that carry it: in a 28-day split-face study in 24 volunteers, a dissolving microneedle patch with the peptide at 0.03% alongside two other actives at 5% and 4% improved eye wrinkles, water loss, elasticity and lifting against a plain hyaluronic-acid patch on the opposite eye. Longer studies of serums and patches carrying it among several actives report crow's-feet severity and fine lines falling against subjects' own pre-treatment skin.
- topical anti-wrinkle formulations
- the look of expression lines around the eyes
- eye serums and creams
- microneedle patch delivery
- combination peptide blends
Common areas of interest, not measured results. The findings below are the published data.
In a 28-day split-face study in 24 healthy volunteers, a dissolving microneedle patch containing 0.03% acetyl octapeptide-3 alongside 5% ascorbic acid 2-glucoside and 4% sodium cyclic lysophosphatidic acid improved eye wrinkles, transepidermal water loss, elasticity and lifting versus a hyaluronic-acid-only placebo patch on the opposite eye; the peptide was the smallest of three actives and no result isolates it.5
In an uncontrolled 12-week study, hyaluronic acid microneedle patches loaded with acetyl octapeptide-3 alongside arginine/lysine polypeptide, palmitoyl tripeptide-5, adenosine and seaweed extracts showed fine lines and wrinkles down 25.8%, hydration up 15.4% and dermal density and thickness up 14.2% and 12.9%, each against the subject's own baseline with no placebo arm. Five actives were present and none was tested alone.6
In a 12-week monadic study, 31 of 33 enrolled women aged 35 to 55 using a commercial serum containing acetyl octapeptide-3 among other neuropeptides, proteins, amino acids and marine extracts had dermatologist-rated crow's-feet wrinkle severity fall 32% and fine-line visibility fall 66% against their own pre-treatment skin. There was no placebo arm and no arm isolating the peptide.7
For laboratory research use only. Not a drug, food, or cosmetic. Not for human or veterinary use, ingestion, or any form of consumption. Sold exclusively to qualified researchers.
